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Palmitoyl tripeptide - 1

Fast Facts             

Type of Ingredient: Peptide

Main Benefits: Smoothes fine lines, increases collagen production, decreases the appearance of pores.

Who Should Use It: Generally, peptides are safe for all skin types.

How Often Can You Use It: For maximum effectiveness, peptides should be applied during both morning and nighttime skincare routines.

Works well with: Getting a facial peel before applying peptide products will help peptides penetrate the skin more deeply.

 

What is Palmitoyl tripeptide - 1? 

peptide is two or more amino acids joined together and is the building block of protein. Peptides fall into three main categories: signal peptides, carrier peptides, and those that inhibit nerve signals. Signal peptides act as messengers to cells thereby trigger collagen synthesis, which then increases skin firmness.

According to Nancy Samolitis, MD, FAAD, "Complete, non-fragmented proteins (like collagen) are not able to be directly absorbed through the top layer of skin, so these smaller pieces can get deep into the cellular level…Peptides are essentially fragmented portions of proteins. So when they're used in skincare, the objective is for those fragments of collagen to stimulate collagen growth.”

Palmitoyl tripeptide – 1 is a small three amino acid signal peptide with the amino sequence of glycine-histidine-lysine (GHK). GHK is attached to palmitic acid (a fatty acid) to increase its skin penetration and oil solubilty. Applying palmitoyl tripeptide – 1 directly to your skin, tells the cells to make more collagen, stimulating new collagen production. It requires at least 1 month or more to begin to see visible changes from new collagen with maximum results visible after 3-4 months.

Erin Gilbert, MD, FAAD, Ph.D., and board-certified dermatologist and neuroscientist, continues: "Peptides can be included in serums, moisturizers, and masks," Gilbert explains. "They are also included in some topical serums used after micro-needling or superficial laser procedures to increase the penetration of the peptide and help the skin recover from the procedure."

           

The Benefits of palmitoyl tripeptide - 1

Here are the specific benefits to                    

  • Firms the skin and aids in collagen production: As we age, collagen in the skin breaks down into peptides which send signals to skin cells, informing them to make more collagen to replace what was lost. Topical application of peptides increases this signalling, thereby increasing new collagen production.
  • Reduces the appearance of fine lines: By stimulating collagen production, peptides help to make the skin appear more plump and youthful.
  • Strengthens skin barrier: Peptides increase cell activity and repair the skin’s natural barrier function of retaining water and protecting the body against foreign substances.
  • Locks in hydration: As you age, collagen production declines and over time, collagen level in the skin decrease.       Collagen aids the skin in retaining moisture, hence the loss of collagen also causes dehydration in the skin. When peptides help boost collagen production, it also boosts hydration in the skin.
  • Has anti-inflammatory properties: Antioxidants found in peptides help calm and soothe your skin, leading to less inflammation.
  • Smooths out complexion: With upped collagen production comes clearer, more even skin, too.

 

 

SAFETY

The CIR Expert Panel concluded that peptides as cosmetic ingredients are safe in the present practices of use and concentration in cosmetics and self-care products. Environmental Working Group (EWG) currently rates palmitoyl tripeptide-1 a 1. Overall, peptides such as palmitoyl tripeptide -1 mimics what already exists in the human body and research on peptides impact on the skin shows limited to no skin irritation. In terms of toxicity caused by peptides, there is no published research to document any know toxicity.

 

References:  

Topical Peptide Treatments with Effective Anti-Aging Results, Cosmetics 2017, 4(2), 16; https://doi.org/10.3390/cosmetics4020016

https://www.cir-safety.org/sites/default/files/tripep062014final.pdf

https://www.cir-safety.org/sites/default/files/palmit072012slr.pdf