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Ingredient: Palmitoyl Tripeptide-1

Fast Facts

Type of Ingredient: A type of peptide, which is the building block of protein

Main Uses and Benefits: Smoothes fine lines, increases collagen production, and decreases the appearance of pores.

Find It In: Anti-aging moisturizers, serums, and masks. You can also find it in post-procedure serums to help the skin heal faster.

How Often Can You Use It: Generally, peptides are safe for all skin types. For maximum effectiveness, peptides should be applied during both morning and nighttime skincare routines. Getting a facial peel before applying peptide products will help peptides penetrate the skin more deeply.

What Is Palmitoyl Tripeptide-1?

A peptide is two or more amino acids joined together and is the building block of protein. Peptides fall into three main categories: signal peptides, carrier peptides, and those that inhibit nerve signals. Signal peptides, like palmitoyl tripeptide-1, act as messengers to cells, which trigger collagen synthesis, which then increases skin firmness.

Palmitoyl tripeptide-1 is a small three amino acid signal peptide with the amino sequence of glycine-histidine-lysine (GHK). GHK is attached to palmitic acid (a fatty acid) to increase its skin penetration and oil solubility.

The Benefits of Palmitoyl Tripeptide-1

Applying palmitoyl tripeptide-1 directly to your skin tells the cells to make more collagen, stimulating new collagen production. It requires at least one month or more to begin to see visible changes from new collagen with maximum results visible after 3 to 4 months. Erin Gilbert, MD, FAAD, Ph.D., and board-certified dermatologist and neuroscientist, continues: "Peptides can be included in serums, moisturizers, and masks," Gilbert explains. "They are also included in some topical serums used after micro-needling or superficial laser procedures to increase the penetration of the peptide and help the skin recover from the procedure."

Here are the specific benefits of palmitoyl tripeptide-1 to your skin:

1. Firms the skin and aids in collagen production

As we age, collagen in the skin breaks down into peptides, which send signals to skin cells, informing them to make more collagen to replace what was lost. Topical application of peptides increases this signalling, thereby increasing new collagen production.

2. Reduces the appearance of fine lines

By stimulating collagen production, peptides help to make the skin appear more plump and youthful.

3. Strengthens the skin barrier

Peptides increase cell activity and repair the skin’s natural barrier, allowing it to retain water more efficiently and protect the body against foreign substances.

4. Locks in hydration

As you age, collagen production declines and over time, collagen level in the skin decreases. Collagen aids the skin in retaining moisture; hence, the loss of collagen also causes dehydration in the skin. Using collagen-stimulating peptides, such as palmitoyl tripeptide-1, thereby boost skin hydration by boosting collagen production.

5. Reduces inflammation

Antioxidants found in peptides help calm and soothe your skin, leading to less inflammation.

6. Smooths out complexion

Increased collagen also means clearer, more even skin, too.

Safety: Is Palmitoyl Tripeptide-1 Safe?

The CIR Expert Panel concluded that peptides, such as palmitoyl tripeptide-1, are safe in cosmetics and self-care products. Environmental Working Group (EWG) currently scores palmitoyl tripeptide-1 as “1” or “low hazard.”

Overall, peptides, such as palmitoyl tripeptide-1, mimic what already exists in the human body and research on peptides’ impact on the skin shows limited to no skin irritation. In terms of toxicity caused by peptides, there is no published research to document any known toxicity.