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Ingredient: Palmitoyl: Tetrapeptide-7

Fast Facts           

Type of Ingredient: A type of peptide, known for its skin-restoring and anti-aging abilities   

Main Uses and Benefits: Enhances a product's stability and penetration into the skin. Replenishes the skin's surface and calms visible signs of skin sensitivity.

Find It In: Skincare products for wrinkles, sagging, and uneven skin tone

How Often Can You Use It: You can use it daily.

What Is Palmitoyl Tetrapeptide-7?  

Palmitoyl tetrapeptide-7 is a synthetic peptide made of four amino acids: glycine, glutamine, proline, and arginine sequence. These amino acids provide anti-aging effects by stimulating cell production and boosting the renewal process, working on the molecular levels in the skin layers.

Palmitoyl tetrapeptide-7 is also used in beauty and cosmetic products to suppress the production of excess interleukins, the chemical messengers that trigger the body’s acute inflammatory response. Inflammation negatively affects the skin's support system (comprised of collagen, elastin and other proteins) and leads to wrinkles, sagging, and uneven skin tone. 

What are the Benefits of Palmitoyl Tetrapeptide-7

1. Helps regenerate skin

According to Jacqueline Schaffer, M.D., anti-aging expert, best-selling author, and founder of vegan skincare brand Schique, palmitoyl tetrapeptide-7 helps regenerate the skin by boosting the production of collagen, the building blocks of skin. “These are regenerating peptides that stimulate collagen production, as well as suppress the body’s acute inflammatory response,” she explains.

2. Helps fight skin inflammation and glycation

Studies have shown that palmitoyl tetrapeptide-7 can slow or suppress the production of excess interleukins, therefore inhibiting unnecessary inappropriate inflammatory responses and glycation damage.

Interleukin is a chemical often associated with inflammation, as the body creates it in response to damage.  By blocking this chemical, palmitoyl tetrapeptide-7 relieves some of the chemical pressure on the skin and allows it to heal faster.

In vitro, scientists found that "Palmitoyl tetrapeptide-7 induced a marked dose-dependent reduction in interleukin production. The higher the concentration of palmitoyl tetrapeptide-7, the greater the reduction in interleukin production – up to 40%."

3. Helps reverse UV damage

UV radiation is also known to accelerate interleukin production. Cells exposed to UV radiation and then treated with palmitoyl tetrapeptide-7 saw an 86% reduction of interleukin production.

The higher concentration of this chemical in beauty products may reduce the production of interleukin to up to 40 percent. 

Here are other skin benefits of palmitoyl tetrapeptide-7

  • Palmitoyl tetrapeptide-7 may also reduce problems with skin roughness, fine lines, thin skin, and wrinkles.
  • The proper proportion of palmitoyl tetrapeptide-7 and palmitoyl-oligopeptide in cosmetic products induces natural collagen production for skin healing and rejuvenation.
  • May help treat rosacea
  • Helps reduce the appearance of uneven skin tones

Palmitoyl Tetrapeptide-7 in Skincare Products

Palmitoyl tetrapeptide-7 is a relatively common ingredient in anti-aging serums, night creams, anti-wrinkle creams, under-eye concealers, moisturizers, and hyperpigmentation treatments. It is important to remember that this chemical will rarely be the only active ingredient in the product, and is just part of the overall treatment. Hence, its concentrations may be negligible in a skincare product. Prolonged use may have more profound effects on skin tone.

Is Palmitoyl Tetrapeptide-7 Safe for Skin?

Palmitoyl tetrapeptide-7 is an FDA-tested and listed product, believed to carry little, if any, dangers of toxicity. Research suggests that this ingredient is safe for use in dermatological products, although overuse may lead to skin discoloration issues.

There are no believed side effects associated with using products containing palmitoyl tetrapeptide-7. This synthetic compound is thought to be generally suitable for use on most skin types without significant risk of rash or irritation and is considered to be non-toxic. However, keep in mind that even non-toxic ingredients may cause allergic reactions to certain skin types.