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Angelica Polymorpha Sinensis Root Extract (Dong Quai)

Angelica Polymorpha Sinensis Root Extract

Fast Facts       


Type of Ingredient: Antioxidants, known as Dong Quai

Main Benefits Treats dark under-eye circles, rosacea skincare, varicose veins, and general anti-aging skincare

Who Should Use It: Used for people with aging skin

Ideal For These Concerns: Hyperpigmentation, wrinkles, dryness, free radicals damage, sun damage, and fine lines.       

How Often Can You Use It: You can use it daily.



What is angelica polymorpha Sinensis root extract? 

Angelica polymorpha Sinensis root extract is an herbal extract derived from the root of the plant Angelica Sinensis with possible antiinflammatory, antispasmodic, vasodilatory, estrogenic, and antitumor activities. Angelica Sinensis contains volatile oils, including safrole, isosafrole, and n-butylphthalide; coumarin derivatives, including psoralens, bergapten, osthol, imperatorin, and oxypeucedanin; and ferulic acid. The coumarin derivatives in this agent may vasodilate and relax smooth muscle and may exhibit additive anticoagulant effects. Ferulic acid, a phenolic phytochemical present in plant cell walls, may neutralize free radicals such as reactive oxygen species. Besides, Angelica Sinensis extract has been shown to inhibit the growth and induce apoptosis of glioblastoma multiform brain tumor cells through p53-dependent and p53-independent pathways. Check for active clinical trials using this agent. (NCI Thesaurus)


 The Benefits of angelica polymorpha Sinensis root extract

The indications for this herb in TCM are clear, to circulate and nourish the blood. Here we are referring to the system of Blood and not the liquid we commonly think of in our veins. The herb is sweet, acrid, bitter and warm. These are all energetic qualities known to harmonize and invigorate. It is used for convalescence, and feelings of weakness, chilliness, and frailty, especially in Women. The herb alone and in conjunction with other botanicals in the formula provides a natural hormonal balance during the onset of menopause and is good support for the peri-menopause and menopausal years.

The beneficial qualities of Angelica root have been extracted and naturally preserved in a base of certified organic plant glycerin to make this extract. This herb has significant anti-aging properties - scientific testing has established its ability to block collagenase and elastase, the enzymes which cause break down of collagen & elastin.  It is also a powerful skin detoxifier assisting with acne, clogged pores and irritations so are particularly suitable for oily skin.  

To develop a new whitening agent for cosmetics from natural products, Angelica dahurica was selected for its inhibitory effect on melanogenesis in B16 melanoma cells. From the mechanism study, it was clarified that the ethanolic extracts of this plant showed the suppression of tyrosinase synthesis but no inhibition of tyrosinase activity. To find the active constituents from this plant, the ethanol extracts were chromatographed repeatedly with silica gel. Two coumarin compounds were isolated from A. dahurica. Their structures were identified by physicochemical and spectral data such as UV, IR, NMR, and MS. It was shown that the active substance was isoimperatorin (10-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g][1] benzopyran-7-one) and imperatorin (9-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g][1] benzopyran-7-one). They significantly inhibited tyrosinase synthesis in B16 melanoma cells. To elucidate the action mechanism of the active compounds of A. dahurica, we investigated the changes in the mRNA level of tyrosinase using the RT-PCR technique. As a result, the mRNA level of tyrosinase was markedly reduced by active compounds of A. dahurica. From these results, we suggest that these extracts might be useful as a new whitening agent in cosmetics, but the in vitro findings must be verified in vivo skin-lightening studies.



Because the U.S. Food and Drug Administration (FDA) doesn’t regulate Dong Quai, its side effects aren’t as well known as those of prescription medicines. However, there are some confirmed side effects and interactions based on its 2,000-year history as a supplement. These include:

  • difficulty breathing
  • drop in blood pressure
  • drowsiness
  • fever
  • headaches
  • increased bleeding risk
  • low blood sugar
  • stomach upset
  • sweating
  • trouble sleeping
  • vision loss

People who are allergic to plants in the carrot family, which includes anise, caraway, celery, dill, and parsley, shouldn’t take Dong Quai. Dong Quai is in the same family as these plants and could cause a reaction.

Other medications Dong Quai may potentially react with include:

  • birth control pills
  • disulfiram, or Antabuse
  • hormone replacement therapy
  • ibuprofen, or Motrin and Advil
  • lorazepam, or Ativan
  • naproxen, or Naprosyn and Aleve
  • topical tretinoin

Blood thinners like warfarin, or Coumadin, in particular, can be dangerous with dong Quai.

This list isn’t comprehensive. Always talk to your doctor before starting to take it, and read the manufacturer’s recommendations carefully about how much to take.