This site has limited support for your browser. We recommend switching to Edge, Chrome, Safari, or Firefox.

Peptides for Mature Skin: Introduction and Best Options

Skin maturation can occur after the age of 25, but it is highly dependent on your specific genetics and environmental variables. Surprisingly, when it comes to this type of skin, your biological age does not necessarily matter. Some people may see skin maturation as early as 30, while others may not notice it until they are 60 or later.

Aging in the skin occurs when changes in the body make it more difficult for the skin to preserve its young radiance. It might be caused by aging, when collagen and sebum synthesis decreases. You're also more prone to dehydration, which can have an impact on your skin's look. Hyperpigmentation, often known as dark patches, might appear.

All of these changes might cause your previously lush, smooth skin to become drab and drier. While developed skin isn't exactly a skin type, it can be problematic for people of all ages and skin types.

What is Skin Aging?

Source: Hollywood Skin

The complexion of mature skin is often duller. It might be dry and pallid, have open pores, or be hyperpigmented. People with older skin may have visible wrinkles as a result of thinner or drier skin.

If you have this type of skin, you may also have uneven skin tone or sagging, which distinguishes it from dry or sensitive skin.

Factors that Can Lead to Skin Aging

Photoaging Due to Ultraviolet (UV) Damage

One of the biggest causes of aged skin is sun exposure. It has the potential to harm cell DNA, resulting in pigmentation, diminished elasticity, and accelerated skin aging.

Sleep Deprivation

Getting adequate sleep allows your body to rebuild skin cells and maintain a youthful appearance. Lack of sleep, on the other hand, can weaken your skin's natural protective barrier and accelerate intrinsic aging.


Chronic stress causes the skin to mature prematurely because it raises cortisol levels in the body, which limit collagen formation in the skin. Collagen helps skin maintain its structure and fullness, and while collagen synthesis normally declines with age, stress can hasten the process!

Inadequate Exercise

A sedentary lifestyle can also limit collagen formation and hasten cell aging, resulting in aged or sagging skin. Another incentive to prioritize regular exercise!

Alcohol and tobacco

Because smoking and drinking can contribute to DNA damage and aging skin, cutting back on these drugs can help prevent older skin!

Chronic Health Issues

Diabetes and certain drugs, for example, have a role in the development of mature skin. Declining estrogen, which is common after menopause, can also hasten the aging process of the skin.

Information cited from AgeLessGlowSkin

Individuals with dry skin are also more prone to having this type of skin due to premature lines and wrinkles, which is why knowing your skin type and taking excellent care of your skin is critical.

How to Take Care of Mature Skin

Wrinkle creams, eye serums, and other anti-aging skin care treatments can help reduce the appearance of wrinkles. However, in order to establish a genuinely successful anti-aging skin care regimen, it is necessary to begin with good skin care practices. Healthy skin care routines have the following advantages:

    • Prevent (or eliminate) blotchy skin.
    • Maintain skin's young suppleness for a longer period of time
    • Reduce the appearance of fine lines and wrinkles.
    • Keep your skin appearing younger and brighter.
    • Avoid skin that is leathery.
  • Reduce your risk of skin cancer.

  • Sun protection is essential for your skin. Sun protection is the cornerstone of every anti-aging skin-care regimen. The sun's rays accelerate the aging process of our skin. There is so much proof that the sun prematurely ages our skin that there is a term to describe it. This is the term "photoaging."

    Forget about tanning inside. UV (ultraviolet) rays are emitted by the sun, tanning beds, and sun lamps. These rays hasten skin aging.

    Every day, apply moisturizer. Skin grows drier as we age. Wrinkles and fine lines emerge. Moisturizer holds water in our skin, making it seem younger. Use a face moisturizer, body moisturizer, and lip balm for the greatest effects.

    Quit smoking. Toxins in tobacco smoke can cause smokers' faces to swell. Smokers' faces exhibit dull and dry skin, loss of skin firmness, premature lines and wrinkles, and leathery skin.

    Consume nutritious foods. A nutritious diet supports good skin. Consume an abundance of fruits and vegetables, lean proteins, and healthy fats.

    Get adequate rest. There's a reason it's called beauty rest. Sleep allows your body to rejuvenate and regenerate itself.

    What are Peptides?

    "Peptides are strings of amino acids, which are the building blocks that make up proteins in our bodies, including collagen in the skin," explains Dr. Whitney Bowe, a famous dermatologist and author located in New York City. "Without these proteins, we would notice wrinkles, brittle nails, and dry, brittle hair."

    Peptides are found in every human cell and play a vital part in how the body operates, frequently functioning as a biological messenger, in addition to being necessary to the structure and function of the skin (key factors in firmness, texture, and overall look). "Peptides are required at all times." "Our bodies cannot operate if we are deficient in them," explains Dr. Robinson. "Peptides have a variety of functions in the body, including serving as the building blocks for proteins."

    Not all peptides are made equal when it comes to skin care. "While there are hundreds of peptides, certain peptides are more effective for the skin than others," Dr. Robinson adds. Carrier peptides, for example, supply trace minerals to the skin to enhance collagen, whereas enzyme inhibitor peptides help to halt the skin's natural collagen degradation. Signal peptides provide information to different sections of the skin to boost collagen, elastin, and other proteins, while neurotransmitter peptides, dubbed "Botox-like," prevent the release of chemicals that trigger muscle contraction in expression lines, smoothing wrinkles.

    Benefits of Peptides

    • Skin barrier improvement

    The skin barrier protects the body from pathogens, UV radiation, pollution, and other poisons. Excessive exfoliation, cigarette smoke and other pollutants, and even lack of sleep can all harm the skin barrier. Peptides aid in the formation of a stronger barrier.

    • Wrinkles have been reduced

    Collagen has the ability to fill the skin and lips. Wrinkles and fine lines will be less evident when the skin is firmer and plumper.

    • Skin that is more stretchy

    In addition to collagen, peptides are found in elastin fibers, which are also proteins. These fibers give the skin a firmer and tauter appearance.

    • Relieves inflammation

    Peptides can aid in the reduction of inflammation, the restoration of damaged skin, and the evenness of skin tone.

    • Can help with outbreaks

    Some peptides are antimicrobial, which means they can fight acne-causing bacteria.

    How to Choose a Peptide

    Choose a leave-on product.

    Avoid rinse-off products like cleansers and masks (they don't remain on long enough to enter skin and provide any benefits), and instead use a leave-on product. Dr. Doft recommends using a peptide-rich serum or moisturizer (such as a day or night lotion) twice daily.

    Use it with Retinol

    Peptides are excellent anti-aging chemicals, but they are not a substitute for retinol (FYI, retinol is the gold standard when it comes to anti-aging). According to dermatologist Corey L. Hartman, MD, for maximum skin smoothing and firming results, you'll want to incorporate both retinol and peptides into your daily routine. "You can either use these ingredients together at night or use just peptides in the morning and a retinol in the evening." Also, pregnant women cannot use retinol, so peptides should be used solely.

    Keep that Eye Hydrated

    A peptide-infused eye cream is another excellent option to include peptides into your everyday skincare routine. While effective, retinol might be too abrasive for the sensitive skin around your eyes. Peptides, on the other hand, are a more secure option. They can help firm and tighten skin and reduce the look of crow's feet and crepey texture without causing irritation when used in an eye cream or serum. 

    Best Peptides for Mature Skin

    Acetyl Tetrapeptide-15

    This cosmetic peptide is used to care for sensitive skin. The tetrapeptide works on neuro sensitive skin by reducing the release of pro-inflammatory mediators and raising skin tolerance, making the skin less reactive and minimizing the sense of pain and discomfort.

    Acetyl tetrapeptide-15 has a similar impact to natural opioids. They inhibit the action of pain receptors (nerve endings). This lowers the sense of pain and discomfort caused by variables that cause skin sensitivity.

    In vitro clinical research revealed that reducing the relaxation of the neurotransmitter CGRP (Calcitonin Gene Related Peptide) in sensory neurons lowered skin sensitivity responses. Acetyl tetrapeptide-15 has also been demonstrated to serve as an opioid receptor agonist. In vivo clinical investigations demonstrated that this lowers pain.

    Acetyl hexapeptide-8

    It is a peptide chemical intended to minimize the appearance of tiny lines caused by repetitive facial expressions, such as crow's feet, glabellar lines, or nasolabial lines. It is sometimes referred to as 'Botox in a jar.' It is also known commercially as Argireline, which can refer to either acetyl hexapeptide 8 or acetyl hexapeptide 3.

    It encourages the skin's natural synthesis of type 1 collagen, a critical protein that creates big, eosinophilic fibers to restore muscles and reduce fine lines and wrinkles. Because this substance prevents nerve impulses from reaching the muscles, the muscles can no longer retract, allowing wrinkles to relax and soften. Sun-damaged wrinkles and fine lines will not react to acetyl hexapeptide 8.

    Arginine/Lysine Polypeptide

    Arginine/lysine polypeptide is a multi-peptide manufactured in a laboratory that is based on the skin-friendly amino acids l-arginine and l-lysine. These amino acids are oligopeptides, which are shorter peptide chains made up of at least two (but no more than twenty) amino acids.

    In terms of concentration, the suggested quantity to use for observable results is between 0.4-2 percent of this mix. Because both amino acids that make up this peptide are naturally abundant in skin, arginine/lysine polypeptide is thought to be safe and non-irritating.

    Palmitoyl Tripeptide-5

    Palmitoyl tripeptide-5 is a synthetic peptide composed of three chains of amino acids linked by fatty acids. Palmitoyl tripeptide may permeate the epidermis and penetrate deep into the dermis, where it can stimulate collagen formation and promote the development of healthy tissue.

    For ages, the skincare industry has revolved on the application of natural oils and skin lightening treatments to the skin. Palmitoyl tripeptide is a novel peptide that was found lately. These molecules occur naturally in our bodies, but because of their prominence as anti-aging agents, several skincare businesses are now synthesizing them in the lab to give better control over the effects. It is a transparent liquid that is water soluble and odorless. It is most often found in anti-aging creams.

    Acetyl Tetrapeptide-2

    Acetyl tetrapeptide-2 is most typically used as a skin conditioner since it soothes and nourishes the skin in the same way that other peptides do. It accomplishes this by compensating for hormone loss in the skin, particularly collagen, and delivering a plumping effect to the skin.

    According to the Cosmetics Database, it contains anti-inflammatory qualities. There have previously been claims that the ingredient, as part of the Neopeptide product, can assist in the treatment of alopecia; however, after delving a bit deeper into the literature on the matter, we have no reason to assume that acetyl tetrapeptide-2 actively promotes hair development.

    Palmitoyl Dipeptide-7

    Palmitoyl Tetrapeptide-7 is a four-amino acid synthetic peptide used in beauty goods and cosmetics to reduce the generation of excess interleukins, the chemical messengers that initiate the body's acute inflammatory response. This can result in glycation damage, which is the process by which glucose binds to proteins, stiffening tissues. This has a detrimental impact on the skin's support system, which is made up of collagen, elastin, and other proteins, resulting in wrinkles, sagging, and uneven skin tone.

    These are the most effective peptides for mature skin. Finally, due to the hydrolysis vulnerability of peptides, we do not advocate mixing direct acids with them (which breaks the bonds between peptides, reducing their efficacy, and making them into individual amino acids).