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Matrixyl Synthe 6: Aging the Better Way

Aging is an unavoidable reality of life. There are two types of skin aging processes: intrinsically and extrinsically.

Intrinsic aging is the slowing of normal cellular and biological activities. The skin's strong collagen and elastic matrix weakens over time, decreasing cell turnover and leading to hyaluronic acid, elastin, and collagen depletion. The skin loses strength and resilience when these important components deplete. Collagen, the protein that creates a matrix between the layers of the skin and makes it seem tight and plump, begins to degrade.

Extrinsic aging is caused by a number of external factors that accelerate the aging process, such as lifestyle decisions such as smoking, alcohol use, and lack of exercise, as well as environmental stressors such as pollution, blue light radiation, and smoking.Years of sun exposure, on the other hand, might result in dark patches that no longer fade (hyperpigmentation, darker spots on the skin, can also occur after an acne breakout). 

What is Matrixyl Synthe 6

Matrixyl Synthe 6 may make your skin appear its finest and shine by boosting radiance and brightness and reinforcing the skin's natural barriers and defenses.Matrixyl Synthe'6 is palmitoyl tripeptide-38, a peptide made from lysine and methionine sulfone derivatives (the latter is synthetic). Palmitoyl tripeptide-38 is a matrikine-like molecule that controls cell activity, wound healing, and collagen tissue remodeling.

Matrixyl synthe'6 is a deoxygenated lipopeptide that promotes the synthesis of six main components of the skin's matrix and dermal-epidermal junction (collagen I,III, IV, fibronectin, hyaluronic acid). As a consequence, wrinkles are smoothed out as the skin is regenerated from the inside.

Matrixyl anti-aging skin care products stimulate collagen production, which is required to decrease wrinkles and fine lines, particularly on the face. Consumers may be interested to learn that studies have demonstrated significant improvement after just two months of usage.

Peptides, also known as polypeptides, are naturally occurring molecules found in our skin. Peptides, in the most basic sense, are amino acids that build up the proteins that our skin needs to look and feel healthy. They construct these proteins by forming chains (combinations).

Collagen, for example, is composed of three peptide chains. Collagen is the building block of our skin's structure and is arguably the most significant protein for our skin. Collagen synthesis begins to decline as we age. As a result, the skin loses firmness, has an inconsistent tone and texture, and fine lines and wrinkles appear.

Peptides alert the skin that it's time to make collagen and hyaluronic acid. Matrixyl Synthe'6 is a peptide that activates six key skin areas:


Collagen I

The primary component of the skin's deepest layers.

Collagen III

This kind of collagen is created during the early stages of wound healing, prior to the commencement of type I collagen synthesis. It is found mostly in elastic tissues such as the skin, muscles, and blood vessels, and it declines with age in favor of collagen I.

Collagen IV

This collagen interacts with keratinocytes, which increase epidermal cell proliferation soon after a skin injury, and hence has crucial wound healing stimulating capabilities.


A glycoprotein that appears to have a role in the stimulation and acceleration of in vivo tissue repair.

Hyaluronic acid

Hyaluronic acid, well-known for aiding wound healing, is supposed to increase skin hydration and flexibility. Hyaluronic acid has been shown to improve the distribution of active substances to the skin's inner layers. Because of its free radical scavenging characteristics, it may possibly play a role in UV protection.


Laminins, like collagens and proteoglycans, are key basement membrane components. Laminin-5 connects the epidermis and dermis. It also controls keratinocyte migration, which aids in the repair of damaged epidermis.

Matrixyl in this form helps to regulate cell activity, rebuild collagen tissue, and aid in wound healing. Indeed, Matrixyl Synthe'6 has the ability to operate on important parts of the skin's structure, assisting with more advanced cases of deep wrinkles.

Matrixyl Synthe'6 also protects against heat shock, which occurs when your cells are subjected to high temperatures and other environmental stresses. Finally, this type of Matrixyl has a significant influence on increasing the quantity of Hyaluronic Acid produced by the body.

Active Ingredients in Matrixyl Synthe 6

Palmitoyl tripeptide-38 is a matrikine-like molecule that controls cell activity, wound healing, and collagen tissue remodeling. It stimulates six primary skin matrix constituents and the dermal-epidermal junction to fill fine wrinkles and improve skin healing.

Palmitoyl Pentapeptide-4 is a synthesized pentapeptide chain protein formed by joining five amino acid peptides. According to studies, this chain causes a reaction in the skin's dermis that activates collagen and elastin fibroblasts, resulting in the development of fibronectin (FN) and glycosaminoglycans (GAG). Palmitoyl Pentapeptide-4 is a tiny molecule that quickly enters the skin and is structurally comparable to collagen type I precursor. It is believed that pentapeptides can communicate with cells and program them to perform specific tasks, such as repair work.

Palmitoyl Pentapeptide-4 is thought to be as effective as retinol but less irritating. According to, "one study discovered that Palmitoyl Pentapeptide-4 was as effective as retinol in repairing sun-damaged skin but had no side effects."

Hyaluronic acid

Hyaluronic Acid is a gel-like material with the extraordinary capacity to retain moisture. In fact, our bodies naturally manufacture it to aid in the retention of moisture in our skin. It also exists in our eyes, joints, and connective tissue. As we age, we generate less and less Hyaluronic Acid, causing our skin to become drier and less elastic, resulting in deep-set wrinkles. Because Hyaluronic Acid can store 1,000 times its weight in water, it works beautifully as an anti-aging component in face creams and serums.

Benefits of Hyaluronic Acid

  • Skin hydration - keeps your skin hydrated and glowing.
  • Anti-wrinkle characteristics - Because of its ability to retain significant amounts of water, skin remains moisturized and helps to prevent the formation of wrinkles, as well as filling in existing wrinkles to lessen their appearance.
  • Healing characteristics - applying Hyaluronic Acid to wounds has been demonstrated to help reduce the size of surface wounds on the skin, as well as relieve pain in these regions.
  • Antioxidant - aids in the maintenance of healthy skin.

Benefits of Matrixyl Synthe 6

Matrixyl Synthe'6 is a potent lipopeptide that promotes the synthesis of six important cell-building components found in the skin's matrix. This peptide serum, combined with fibronectin and hyaluronic acid, helps to repair numerous forms of collagen present in the skin that are highly useful.

Matrixyl Synthe'6 aids in the restoration of collagen and elastin while strengthening the skin's matrix, which includes:

  • reducing the visibility of prominent wrinkles
  • Increasing skin firmness
  • Increasing the overall texture.
  • Restoring photodamaged skin

Matrixyl Synthe 6 serum for skin is the way to go if you want to reverse the symptoms of aging. For a more strong, concentrated therapy, this serum tackles deep wrinkles, loss of firmness, and sun-damaged skin. Matrixyl's active component (Palmitoyl Pentapeptide) encourages the synthesis of new collagen, elastin, and hyaluronic acid, which assists in naturally filling creases from inside the skin.

Does Matrixyl for skin really reduce pores

Contrary to popular belief, pores cannot be opened, closed, or reduced. They can, however, be cleaned and decongested to shrink in size. Matrixyl 300 and Matrixyl Synthe'6 are peptides with collagen-building and moisturizing properties. Both of these potent chemicals work together to block open pores, while hyaluronic acid draws moisture from the internal or external environment to keep the skin moisturized.

When you apply this serum, your pores are continually filled with hydrating molecules, keeping your skin hydrated and fresh while also minimizing open pores for long-lasting hydration!

How to Use It

For targeted treatment, use Matrixyl Synthe'6 on more prominent lines and wrinkles and Matrixyl 3000 on all other desirable regions. Apply two to three drops of serum to clean skin with your fingertips, either in the morning or at night. Apply it up to twice a day for optimum benefits, once in the morning and once at night.

Matrixyl, unlike retinol, is less likely to produce irritation and harmful skin side effects such as increased risk of UV damage. There's no need to get rid of your retinol or retinoid products if you've been using them for a while. Matrixyl and retinols complement each other wonderfully.

Matrixyl anti-aging skin care products stimulate collagen production, which is required to decrease wrinkles and fine lines, particularly on the face. Consumers may be interested to learn that studies have demonstrated significant improvement after just two months of usage.

Other Matrixyl Series

Matrixyl contains Palmitoyl Penta (or Oligo) peptide, whereas Matrixyl 3000 has this element plus Palmitoyl Tetra (or Tera) peptide.

Matrixyl's active component (Palmitoyl Pentapeptide) encourages the synthesis of new collagen, elastin, and hyaluronic acid, which assists in naturally filling creases from inside the skin.

Matrixyl 3000 (Palmitoyl Terapeptide) does the same thing, but it also prevents and reverses glycation damage. For some people, this extra advantage may make it a superior choice as an anti-aging skin care product.

Both Matrixyl products are peptide serums that seek to repair, restore, and prevent the affects of aging on the skin. Matrixyl 3000  is appropriate for maintenance and prevention, whilst Matrixyl® Synthe'6 is intended for more advanced skin aging.

What Not to Use with Matrixyl Synthe 6

Lactic Acid (AHA) in combination with Salicylic Acid (BHA) + MatrixylAvoid using Lactic Acid and Salicylic Acid together because they are both exfoliators. Matrixyl is the baby form of Retinol and does not mix well with acids, thus do not layer with Lactic Acid. These compounds are also beneficial on their own, so use them with a moisturizing moisturizer to lock them in.

Matrixyl can be disrupted by both high-grade Vitamin C (in the form of L-Ascorbic Acid) and copper peptides. Peptides, on the other hand, can be beneficial retinol partners due to their emollient characteristics, which can help ease the unpleasant side effects that are prevalent with retinoid usage.

The likelihood of unfavorable interactions between Matrixyl and other chemicals is low. In fact, peptides are frequently found in formulations that include Niacinamide, Vitamin C, Retinoids (such as Retinol), and AHAs (Glycolic Acid).

Where Do I Find Matrixyl Synthe 6?

Matrixyl may be found in a variety of anti-aging skincare products and can be combined with other ingredients to maximize its effectiveness. Because our skin ages from head to toe, you may find this strong chemical on the labels of everything from body lotions to eye creams, face serums, and neck treatments.

Is Matrixyl A Gentler Alternative To Retinol?

It's a retinol substitute: A research that compared 0.0003 percent Matrixyl to 0.07 percent retinol discovered that the peptide had similar wrinkle-reducing qualities, but it's kinder and better tolerated by skin.

We don't know about its long-term safety because it's so new. That is, once again, typical. It can take decades to develop this, and Matrixyl just does not have that kind of time!

Considering its purported anti-aging benefits, Matrixyl hasn't convinced us to reconsider peptides. There is yet insufficient independent research to demonstrate that it works as well as retinol. Matrixyl may be an excellent alternative to retinol if you have sensitive skin and can't take it even in modest dosages.

Retinoids are still the preferable option if you can tolerate them. If you want to improve your anti-aging game, prescription Tretinoin will help you more than random peptides.