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Matrixyl 3000: Ingredients and Its Long Term Benefits

What is Matrixyl 3000?

Matrixyl 3000 is an anti-aging product. The word "matrikine" refers to fragmented matrix peptides that can control cell function. Pal-GHK and Pal-GQPR are two matrikines found in MatrixylTM 3000. These two peptides operate together to restore and preserve the skin's young look by acting as messengers of cutaneous restructuration and repair. MatrixylTM 3000 can be found in anti-aging and wrinkle therapy products such as gels, serums, lotions, and creams.

Matrixyl 3000 is a synthetic collagen booster that contains two skin active peptides, palmitoyl oligopeptide and palmitoyl-tetrapeptide-7. These two active substances excite the skin and collaborate with it to improve the skin's inherent anti-aging qualities.

Matrixyl 3000 does not clog pores, leave skin feeling tight, or cause long-term skin damage, as certain skin care components do. It has several skin advantages, including a 33% reduction in the appearance of wrinkle density, a 23% reduction in the appearance of wrinkle volume, and a 20% reduction in the appearance of wrinkle depth.

The paradox is that as chemists, you can synthesize a zillion different peptides, but only a few of them significantly benefit the skin. So, as a consumer, how do you know? We may sound like a broken record here, but the simplest answer is — those that have been put through the ringer of rigorous testing. Sederma, a skin actives expert and producer, was kind enough to give insights into how they develop their cutting-edge peptide solutions. So, let's take a deeper look at how a firm like Sederma generates its star peptides and establish that they genuinely work for skin!

If you're new to skincare or a seasoned pro, you've probably heard about peptides. It's that exotic chemical found in anti-aging creams and serums that normally comes with a hefty price tag. Even in this sophisticated, presumably high-tech ingredient area, there will be some duds.


Active Ingredients

Matrixyl 3000 is a synthetic collagen booster that contains two skin active peptides, palmitoyl oligopeptide and palmitoyl-tetrapeptide-7. These two active substances excite the skin and collaborate with it to improve the skin's inherent anti-aging qualities.

Palmitoyl tetrapeptide-7

Palmitoyl tetrapeptide-7 is a synthetic peptide made of four amino acids: glycine, glutamine, proline, and arginine sequence. These amino acids provide anti-aging effects by stimulating cell production and boosting the renewal process, working on the molecular levels in the skin layers.

Palmitoyl tetrapeptide-7 is also used in beauty and cosmetic products to suppress the production of excess interleukins, the chemical messengers that trigger the body’s acute inflammatory response. Inflammation negatively affects the skin's support system (composed of collagen, elastin and other proteins) and leads to wrinkles, sagging, and uneven skin tone.

Benefits of Palmitoyl tetrapeptide-7 

Helps regenerate skin

According to Jacqueline Schaffer, M.D., anti-aging expert, best-selling author, and founder of vegan skincare brand Schique, palmitoyl tetrapeptide-7 helps regenerate the skin by boosting the production of collagen, the building blocks of skin. “These are regenerating peptides that stimulate collagen production, as well as suppress the body’s acute inflammatory response,” she explains.

Helps fight skin inflammation and glycation

Studies have shown that palmitoyl tetrapeptide-7 can slow or suppress the production of excess interleukins, therefore inhibiting unnecessary inappropriate inflammatory responses and glycation damage.

Interleukin is a chemical often associated with inflammation, as the body creates it in response to damage.  By blocking this chemical, palmitoyl tetrapeptide-7 relieves some of the chemical pressure on the skin and allows it to heal faster.

In vitro, scientists found that "Palmitoyl tetrapeptide-7 induced a marked dose-dependent reduction in interleukin production. The higher the concentration of palmitoyl tetrapeptide-7, the greater the reduction in interleukin production – up to 40%."

Helps reverse UV damage

UV radiation is also known to accelerate interleukin production. Cells exposed to UV radiation and then treated with palmitoyl tetrapeptide-7 saw an 86% reduction of interleukin production.

The higher concentration of this chemical in beauty products may reduce the production of interleukin to up to 40 percent. 

Table made from LeCerre Information

Palmitoyl Oligopeptide (PO) 

Palmitoyl Oligopeptide (PO) is a synthetic protein that is a fragment of collagen combined with palmitic acid to make it more lipophillic, improve its stability, and increase its affinity towards human skin. It has been clinically proven to reduce wrinkle depth by increasing hyaluronic acid and collagen production.

In a study reviewed by the Cosmetic Ingredient Review Expert Panel, the results indicated that there was a statistically significant reduction in deep wrinkles and improved skin texture after 56 days of use at 3%. This study also found improved elasticity in the skin.

Palmitoyl oligopeptide is being researched for its favorable benefits on the skin, particularly for individuals seeking to reduce obvious indications of aging. It is thought to have a similar purpose to retinol, but with less irritation and sensitivity. While palmitoyl oligopeptide is still being researched, preliminary results indicate that it may be a useful anti-aging agent.

Benefits of the Long-Term Use of Matrixyl-3000

Matrixyl 3000 serum is an excellent anti-aging product that promotes elastin and collagen development. By including this serum into their regular beauty routine, both men and women may regain their young appearance. Many anti-aging serums provide just temporary solutions to the problem of aging skin. Matrixyl 3000 serum, on the other hand, provides a long-term treatment to help repair the effects of aging on our skin.

There are two more peptides in Matrixyl 3000: palmitoyl oligopeptide and palmitoyl tripeptide. These new peptides, which have no link to the original peptide, operate together to simulate the look of broken down collagen. When the body believes collagen is being broken down, it produces more collagen and elastin.

Matrixyl 3000 is an excellent anti-aging treatment. Fine lines and wrinkles are decreased by using this wonderful substance. After a period of usage, there is also a noticeable change in blemishes, dryness, and sagging skin. With daily use of Matrixyl 3000 serum, you may expect a healthy glow, less inflammation, improved circulation, and attractive, youthful-looking skin.

Matrixyl 3000: How to Use It

Matrixyl 3000 serum is simple to incorporate into your everyday anti-aging skin care routine. Apply a few dabs on your fingertips each night and gently work into clean, dry skin. Keep in mind that using more than this would be a waste of product and that it should be dabbed onto and massaged into the targeted region.

Serum must come into touch with your skin in order to be effective. As a result, apply it after cleaning but before moisturizing your skin. The cleanser will remove debris and oil that may obstruct the serum's contact with the skin; on the other hand, moisturizing products build a light layer on the skin, which may obstruct the serum's contact with the skin. In the evening, use serum in between using these two products (or as suggested by the serum's usage directions).

Serums have the potential to be incredibly powerful skin care solutions, but because they come in such a wide range, it is unsurprising that there is some uncertainty about what they are and how they should be used. We wish to demystify these fantastic products by providing some pointers on how to use serums to their maximum potential. After all, even the greatest facial serums will fall short if not applied appropriately. With these helpful hints, you can get the most out of your face care serums. It is suggested that you use this product every night. The effects are not instantaneous, but you will most likely notice a difference shortly after.

Why Using Matrixyl Early Benefits You

Matrixyl is a peptide that has been shown to delay the onset of aging symptoms. Matrixyl 3000 is a close relative. It is, in reality, a fusion of two novel peptides, palmitoyl-oligopeptide and palmitoyl-tripeptide. When these two peptides operate together, they can repair broken down collagen, which is important for your skin's suppleness, reducing wrinkles, and preserving a young appearance. Two small research panels suggest that matrixyl 3000 regulates collagen formation better than original matrixyl.


Matrylyl 3000 is often available as a serum that consumers can use as needed. The serum is often used in the morning and at night. This manner, it works underneath makeup all day and rebuilds collagen as the user sleeps. Applying the serum is as simple as dabbing a few drops over clean, dry skin. Because the serum isn't oily, it dries quickly enough for consumers to complete getting ready for and going about their day.

While matrixyl 3000 performs a majority of the work, the results aren't immediate. Normally, you will see a reduction in fine wrinkles and an improvement in elasticity after a few weeks, so be patient. Other healthy skin care treatments, on the other hand, may yield greater or faster results. Washing your face everyday, removing makeup at the end of the day, eating a nutritious diet, not smoking, and applying sunscreen every day are all examples.

Is it  Better than Retinol?

Matrixyl claims to combat wrinkles as good as, if not better than, retinol (the gold standard for anti-aging) - and without the irritants. Is it effective?

This is a difficult one. There are several studies that back up its anti-aging claims. BUT, practically all of them are sponsored by the company. This is common. Because independent skincare research receives little financing, it is up to manufacturers to conduct the majority of the legwork.Matrixyl may be an excellent alternative to retinol if you have sensitive skin that cannot take it even in modest dosages.

Matrixyl is a novel potential wrinkle-fighting activity. According to preliminary study, it is nearly as effective as retinol at eliminating wrinkles - and without the annoying side effects.

Matrixyl anti-aging skin care products stimulate collagen production, which is required to decrease wrinkles and fine lines, particularly on the face. Consumers will be delighted to learn that studies have demonstrated significant improvement within two months of use, which leads to the following advantages:

  • Reduced wrinkles
  • Enhanced firmness
  • Sagging has been reduced.
  • Moisture retention has been improved.

If you dislike Retinol, Matrixyl is an excellent alternative. This pentapeptide composition was developed in 1993, but it wasn't acknowledged as an anti-aging medicine until 2002, when it was presented at the 20th World Congress of Dermatology in Paris, France.In blind trials, Matrixyl was compared to Vitamin C and Retinol in terms of skin roughness and wrinkle depth. The results were amazing, with wrinkle depth reduced by 18% after just 28 days of usage!

Matrixyl eventually falls short of Retinol, but only by a hair. In the long run, retinol will deliver additional anti-aging effects. If you're not a fan of Retinol, Matrixyl has been shown to give highly competitive outcomes and is an excellent alternative solution.

In conclusion, many different compounds are promoted as anti-aging treatments, few trials have been conducted to demonstrate their usefulness. The most thoroughly explored molecules have been vitamin C, alpha-hydroxy acids, and pentapeptides, and their anti-aging properties have been duplicated in the literature. Some interesting experiments on vitamin A and vitamin B derivatives have also been conducted. Other emerging botanicals require additional investigation before conclusions can be drawn that can be applied to their topical use. Moisturizers have been demonstrated to boost skin hydration while also improving skin appearance.

Despite the paucity of evidence, patients continue to utilize a wide range of OTC products. However, for many people, over-the-counter therapies may not be enough to deliver the desired results, and prescription-strength drugs or surgical procedures may be required.