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Collagen Tripeptide: Benefits and Side Effects

Collagen in foods is a chain of roughly 3,000 amino acids. Collagen supplements are made up of a chain of 30 to 100 amino acids.

These two forms of collagen are too large to be absorbed by our intestines as they are. They enter our bodies following digestion by stomach enzymes.

CTPs are made up of three amino acids. CTP varies from ordinary collagens in that it is immediately absorbed by the digestive system. Even more interestingly, CTP has the novel property of being preferentially absorbed by collagen-associated organs such as the skin, bones, cartilages, and tendons.

Source: VogueIndia

Furthermore, CTP has been shown to activate the body's ability to manufacture new collagen.

Collagen is commonly utilized in various forms as a functional component in skin care products, the effect of oral collagen tripeptides (CTPs) supplementation on human skin is unknown. Furthermore, the bulk of the good CTP outcomes reported thus far have not taken into account the influence of meteorological conditions. As a result, we investigated the effect of CTP on skin characteristics in middle-aged women while controlling for climatic change.

Elastin fibers and collagen in the skin diminish naturally as we age, resulting in skin aging, fine lines, and deep wrinkles. With age, the number of glycosaminoglycans (GAGs) in the epidermis and dermis decreases, resulting in a loss in the skin's ability to retain moisture and an increase in skin dryness.

Collagen is the primary structural component of the dermal extracellular matrix (ECM), which accounts for more than 70% of the dry weight of the normal human skin dermis. Collagen has a triple helix configuration (Gly-X-Y)n, with X and Y primarily consisting of proline (Pro) and hydroxyproline (Hyp). Gly-Pro-Hyp is partly hydrolyzed by the brush-border membrane of the intestinal epithelium-bound aminopeptidase N after consumption to remove Gly. The H+-coupled oligopeptide transporter then transports Pro-Hyp, a significant active ingredient of collagen-derived peptides, into small intestine epithelial cells (PEPT-1).


Collagen Tri Peptide

Collagen tripeptide (CTP) is a functional food material with several biological effects such as improving dry skin and wound and bone fracture healing.Collagen peptides are extremely tiny protein fragments derived from animal collagen. Collagen is a protein that is found in cartilage, bone, and skin.

Collagen peptides are produced by dissolving entire collagen proteins into smaller fragments. Collagen peptides appear to accumulate in the skin and cartilage when taken orally. Some skin and joint disorders may benefit from this.

Collagen peptides are utilized in the treatment of aged skin and osteoarthritis. They are also claimed to treat osteoporosis, brittle nails, muscle strength, and a variety of other ailments, although there is no scientific evidence to back up the majority of these claims. Collagen peptides should not be confused with collagen type I (native), collagen type II (native), or gelatin.

Collagen Tripeptide

  • Collagen in food consists of long chains of  3,000 amino acids, which is too big to be absorbed into the intestine.
  • Generally, collagen supplements are made from collagen with 30 to 100 pieces of amino acids.
  • Collagen Tripeptide is the smallest collagen unit, consisting of 3 amino acids (Glycine- Proline- Hydroxyproline), the most common tripeptide in collagen. 
  • High bioavailability and digestibility. The molecular weight of Collagen Tripeptide is very small, at about 500 dalton (Da), which is 600 times smaller than a general collagen molecule.
  • Smaller molecular Collagen Tripeptide makes it easy and fast to absorb directly into the intestinal tract.


Collagen Tripeptide Vs. Traditional Collagen

Source: Tokyoninki

CTP differs from conventional collagens - it is absorbed by the intestinal tract directly. Even more surprisingly, CTP has the innovative characteristic of being absorbed by collagen-affiliated organs such as the skin, bones, cartilages, and tendons preferentially.Collagen is the main extracellular protein in the body, mostly found in fibrous tissues, such as skin, ligaments, tendons, etc. Collagen peptides are short chain bioactive peptides produced as a result of enzymatic hydrolysis of collagen.

Sources of Collagen

Collagen is found in foods containing gelatin, such as bone broth. Gelatin is a protein material formed from cooked collagen.

Collagen is present in animal connective tissues. Collagen may be found in foods such as chicken skin, hog skin, beef, and fish. Because vitamin C is required for collagen formation, you should consume foods high in this vitamin, such as citrus fruits, broccoli, and bell peppers.

Foods that contain collagen include:

Animal bone broth made from simmering bones in water and a small amount of vinegar anywhere from 4 to 24 hours.

  • Poultry
  • Fish
  • Pork
  • Red meat
  • Dairy
  • Eggs

Plants don’t make collagen, but they do contain nutrients and amino acids that help the body make it.

Foods that contain zinc, vitamin C and sulfur are especially good for assisting with collagen production, these include:

  • Nuts
  • Legumes
  • Soy
  • Broccoli
  • Onions
  • Garlic
  • Berries
  • Leafy greens
  • Tomatoes
  • Whole grains

Digestive enzymes degrade dietary collagen into individual amino acids and peptides. However, collagen in supplements has already been broken down, or hydrolyzed, and is thus considered to be more efficiently absorbed than collagen from meals.


May relieve joint pain

Collagen aids in the preservation of cartilage, the rubbery tissue that protects your joints.

Your risk of degenerative joint problems such as osteoarthritis rises as the quantity of collagen in your body decreases with age. Some research suggests that collagen supplements may help ease osteoarthritis symptoms and lessen overall joint discomfort.

A meta-analysis of five trials involving over 500 persons with osteoarthritis discovered that consuming roughly 10 grams of collagen daily for 24 weeks resulted in substantial reductions in joint stiffness and self-reported joint pain.

Supplemental collagen, according to researchers, may collect in cartilage and drive your tissues to produce collagen. As a result, there may be less inflammation, greater joint support, and less discomfort.

May improve skin health

Collagen is an essential component of your skin. It aids in the strengthening, suppleness, and hydration of the skin. As you get older, your body generates less collagen, which causes dry skin and wrinkles.

Several studies, however, have indicated that collagen peptides or collagen supplements may help prevent the aging of your skin by decreasing wrinkles and dryness. One evaluation of 11 research, largely concentrating on women, discovered that ingesting 3-10 grams of collagen per day for an average of 69 days improved skin suppleness and moisture.

These supplements may help by boosting your body's natural collagen production. Furthermore, collagen supplements may stimulate the development of other proteins that aid in the structure of your skin.

May boost muscle mass

Collagen is an essential component of skeletal muscle since it is the most abundant protein in the body. Collagen supplements may benefit persons with sarcopenia, or the loss of muscular mass that occurs with aging, according to research.

In a 12-week research, 27 males with this ailment were given 15 grams of collagen while engaging in daily activity. Researchers believe that supplementary collagen may boost the synthesis of muscle proteins such as creatine, as well as accelerate muscle development following exercise, when compared to males who did not exercise but did not take collagen.

However, collagen protein is not more efficient than whey protein in terms of muscle or strength growth.

May prevent bone loss

Human bones are mostly composed of collagen, which provides structure and strength. Bone mass deteriorates with age in the same way as collagen does. This can lead to disorders like osteoporosis, which is defined by reduced bone density and an increased risk of bone fractures.

According to research, collagen supplements may help prevent bone disintegration that leads to osteoporosis.

In a 12-month research, women were given either a calcium supplement containing 5 grams of collagen or a calcium supplement containing no collagen. At the conclusion of the research, individuals who took the calcium and collagen supplement had much lower blood levels of proteins that promote bone disintegration than those who simply took calcium.

A research of 66 women who took 5 grams of collagen daily for 12 months revealed comparable benefits. When compared to individuals who did not take collagen, those who did showed an increase in bone mineral density (BMD) of up to 7%. BMD is a measurement of the density of minerals in your bones, such as calcium. Low BMD is linked to weak bones and an increased risk of osteoporosis.

May promote heart health

Collagen supplements, according to researchers, may help lessen the risk of heart disease. Collagen helps to form your arteries, which are the blood vessels that transport blood from your heart to the rest of your body. Without adequate collagen, arteries may lose flexibility and elasticity.

This can lead to atherosclerosis, a condition characterized by artery narrowing. This disorder can result in a heart attack or a stroke. 31 healthy people consumed 16 grams of collagen everyday for six months in a research. From the start of the trial until the end, they had observed a considerable drop in arterial stiffness measurements.

Furthermore, their HDL (good) cholesterol levels increased by an average of 6%. HDL is a major risk factor for heart disease, including atherosclerosis.

Other health advantages of collagen supplements have not been thoroughly researched.

  • Nails and hair Collagen supplementation may strengthen your nails by avoiding brittleness. It may also help your hair and nails grow longer.
  • Gut health is important. Despite the lack of scientific proof, some health practitioners believe that collagen supplements help cure leaky gut syndrome, also known as intestinal permeability.
  • Mental health. Although no studies have been conducted to investigate the impact of collagen supplements in brain health, some people say that they boost mood and reduce anxiety symptoms.
  • Loss of weight. Collagen supplements, according to proponents, may help weight reduction and a quicker metabolism. 


Side Effects of Collagen

If you consume too much collagen, it can disrupt the amino acid equilibrium in your body, causing headaches, digestive difficulties, and exhaustion. Furthermore, some persons may be allergic to or intolerant to collagen.

Collagen supplements are typically well accepted, with few negative effects documented. Some supplements, however, are produced from common food allergens such as fish, shellfish, and eggs. Individuals who are allergic to certain foods should avoid collagen supplements containing these substances.

Some patients have suffered nausea and bloating after using collagen supplements, however these side effects were not caused by the pills. Collagen supplements may also induce digestive adverse effects such as heartburn and a sense of fullness. Regardless, these supplements appear to be safe for the vast majority of people.

  • Constipation
    • Those who take oral collagen peptide supplements complain about the flavor. Aside from that, it may have an impact on your intestinal health. Constipation is one of the potential negative effects of these supplements, according to some consumers. This constipation might be caused by consuming too much protein while not consuming enough drink and fiber.
  • Appetite Suffering
    • Other individuals who use hydrolyzed collagen supplements report a decrease in appetite, while others report feeling bloated. This bloated sensation is caused by stomach acid breaking down the low-molecular-weight collagen peptide, which results in increased gas in the stomach. Because this is only one of the stomach's digestive processes, it should go away soon.
  • Diarrhea
    • Diarrhea is another potential negative effect of using these collagen supplements. This is due to the body using more collagen proteins than it can absorb. The supplements are having difficulty being broken down by the patient's gastrointestinal tract. Those who encounter this symptom should reduce their oral collagen supplement dosage or stop using them entirely.
  • Stones in the kidney
    • Another disadvantage of using oral collagen supplements is the chance of developing kidney stones. Collagen peptide supplements should be avoided by patients who have a history of calcium oxalate kidney stones. It's advisable to start slowly, with 5 to 6 grams per day, however they should still see their physicians.